1159. Echinocandins Dosing in Obese Patients: A Systematic Review
نویسندگان
چکیده
منابع مشابه
Antimicrobial dosing in obese patients.
Although the dose of some drugs is commonly adjusted for weight, weight-related dosage adjustments are rarely made for most antimicrobials. We reviewed the English-language literature on antimicrobial pharmacokinetics and dosing in obesity. Although there are many potential pharmacokinetic consequences of obesity, the actual effect on the pharmacokinetics and clinical efficacy of most antimicro...
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Background. Current guidelines for systemic vancomycin dosing recommended using actual body weight (ABW) regardless of body mass index (BMI). We sought to evaluate the effect of this dosing strategy in obese patients with BMI ≥35. Methods. Retrospective cohort study of patients ≥18 years old with a BMI ≥35 hospitalized between January 1, 2011 and December 31, 2013 with at least 3 doses of intra...
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Deshpande et al. conclude that ethambutol (EMB) doses of 50 mg/kg of body weight twice a week would be the optimal clinical dose for the treatment of Mycobacterium avium (2). This was based on pharmacokinetic-pharmacodynamic studies using a hollow-fiber system model of intracellular M. avium, mimicking ethambutol human-like pharmacokinetics. This adds important information on the relationship b...
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Deshpande et al. conclude that ethambutol (EMB) doses of 50 mg/kg of body weight twice a week would be the optimal clinical dose for the treatment of Mycobacterium avium (2). This was based on pharmacokinetic-pharmacodynamic studies using a hollow-fiber system model of intracellular M. avium, mimicking ethambutol human-like pharmacokinetics. This adds important information on the relationship b...
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The objective of the paper is to review the literature and provide recommendations for use of aminoglycoside antibiotics in critically ill obese patients. Literature search in PubMed for all articles on the use of aminoglycosides in critically ill obese patients was conducted, and all articles related to pharmacokinetics in obesity were reviewed. Bibliographies of all searched manuscripts were ...
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ژورنال
عنوان ژورنال: Open Forum Infectious Diseases
سال: 2020
ISSN: 2328-8957
DOI: 10.1093/ofid/ofaa439.1345